Although Hampton Lakes is close to the US 192 you may find it easier on your first trip to stay on the I- 4 and US 27 as detailed below:
Orlando International approximately 45 minutes:
Follow the exit road out of the airport and travel North towards the 528 Beeline Expressway (Toll Road change needed).
Join the 528 Beeline Expressway and head West to the Interstate 4. (I- 4)
Join the I- 4 and head West towards Tampa.
Leave the I- 4 at exit 55 (previously 23) Junction with Highway 27 (Clermont/Haines City)
Take the left fork on the exit ramp toward US 27 North (Clermont)
Turn left at the lights at the end of the exit ramp
Continue North on US 27 for approximately 4 miles and the entrance to Hampton Lakes is on the right directly after the Palm Key Village which is also on the right
Sanford Airport approximately 60 minutes:
Follow the exit road out of the airport and follow Lake Mary Boulevard for approximately 10 miles to the Interstate 4. (I- 4)
Join the I- 4 heading West signed Tampa.
Leave the I- 4 at Junction 55 and head North on US 27 and continue as directions for Orlando Airport